Rodrigo B Leal

2 papers in the library · publishing 2018

Papers

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Single administration of agmatine reverses the depressive-like behavior induced by corticosterone in mice: Comparison with ketamine and fluoxetine.

Pharmacology, Biochemistry, and Behavior October 2018 Vivian B Neis, Luis B Bettio, Morgana Moretti et al.

Agmatine is a neuromodulator that has been proposed as a therapeutic strategy for the treatment of major depressive disorder (MDD). A previous study reported that agmatine caused a fast-acting effect in mice subjected to chronic mild stress without causing changes in the levels of synaptic proteins in the prefrontal cortex. We examined whether a single administration of agmatine is able to...

DOI: 10.1016/j.pbb.2018.08.005 Full text Agmatine Antidepressant Corticosterone Synaptic proteins

Agmatine potentiates neuroprotective effects of subthreshold concentrations of ketamine via mTOR/S6 kinase signaling pathway.

Neurochemistry International September 2018 Mauren K Tavares, Suellen Dos Reis, Nicolle Platt et al.

Dysregulation of the hypothalamic-pituitary-adrenal (HPA) axis is one of the most robust neurobiological findings in the pathophysiology of major depressive disorder (MDD) over the last 40 years. The persistent increase in glucocorticoids levels induces morphological and anatomical changes in the brain, especially in the hippocampus. Ketamine represents a major advance for the treatment of MDD,...

DOI: 10.1016/j.neuint.2018.05.006 Full text Ketamine Agmatine Akt Ht22 +3