Antidepressant but Not Prophylactic Ketamine Administration Alters Calretinin and Calbindin Expression in the Ventral Hippocampus.
Frontiers in Molecular Neuroscience 2018 Christina T LaGamma, William W Tang, Ashlea A Morgan et al.
Ketamine has been found to have rapid, long-lasting antidepressant effects in treatment-resistant (TR) patients with major depressive disorder (MDD). Recently, we have also shown that ketamine acts as a prophylactic to protect against the development of stress-induced depressive-like behavior in mice, indicating that a preventative treatment against mental illness using ketamine is possible....
DOI: 10.3389/fnmol.2018.00404 (opens in new tab)
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Depression
Dentate gyrus
Doublecortin
Hilus
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