Adolescent Δ9-Tetrahydrocannabinol Exposure and Astrocyte-Specific Genetic Vulnerability Converge on Nuclear Factor-κB-Cyclooxygenase-2 Signaling to Impair Memory in Adulthood.
Biological Psychiatry August 16, 2018 Yan Jouroukhin, Xiaolei Zhu, Alexey V Shevelkin et al.
Background: Although several studies have linked adolescent cannabis use to long-term cognitive dysfunction, there are negative reports as well. The fact that not all users develop cognitive impairment suggests a genetic vulnerability to adverse effects of cannabis, which are attributed to action of Δ9-tetrahydrocannabinol (Δ9-THC), a cannabis constituent and partial agonist of brain...
DOI: 10.1016/j.biopsych.2018.07.024 (opens in new tab)
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Cannabis
Hippocampus
Pyramidal cells
Astrocytes
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