Bagrat Abazyan

2 papers in the library · publishing 2015-2018

Papers

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Adolescent Δ9-Tetrahydrocannabinol Exposure and Astrocyte-Specific Genetic Vulnerability Converge on Nuclear Factor-κB-Cyclooxygenase-2 Signaling to Impair Memory in Adulthood.

Biological Psychiatry August 16, 2018 Yan Jouroukhin, Xiaolei Zhu, Alexey V Shevelkin et al.

Background: Although several studies have linked adolescent cannabis use to long-term cognitive dysfunction, there are negative reports as well. The fact that not all users develop cognitive impairment suggests a genetic vulnerability to adverse effects of cannabis, which are attributed to action of Δ9-tetrahydrocannabinol (Δ9-THC), a cannabis constituent and partial agonist of brain...

DOI: 10.1016/j.biopsych.2018.07.024 Full text Cannabis Hippocampus Pyramidal cells Astrocytes +20

Adolescent cannabis exposure interacts with mutant DISC1 to produce impaired adult emotional memory.

Neurobiology of Disease October 2015 Michael D Ballinger, Atsushi Saito, Bagrat Abazyan et al.

Cannabis is an increasingly popular and controversial drug used worldwide. Cannabis use often begins during adolescence, a highly susceptible period for environmental stimuli to alter functional and structural organization of the developing brain. Given that adolescence is a critical time for the emergence of mental illnesses before full-onset in early adulthood, it is particularly important to...

DOI: 10.1016/j.nbd.2015.06.006 Full text Adolescent development Chronic cannabis use Disc1 Fear memory +1