Astrocytic Mechanisms Involving Kynurenic Acid Control Δ9-Tetrahydrocannabinol-Induced Increases in Glutamate Release in Brain Reward-Processing Areas.
Molecular Neurobiology May 2019 Maria E Secci, Paola Mascia, Claudia Sagheddu et al.
The reinforcing effects of Δ9-tetrahydrocannabinol (THC) in rats and monkeys, and the reinforcement-related dopamine-releasing effects of THC in rats, can be attenuated by increasing endogenous levels of kynurenic acid (KYNA) through systemic administration of the kynurenine 3-monooxygenase inhibitor, Ro 61-8048. KYNA is a negative allosteric modulator of α7 nicotinic acetylcholine receptors...
DOI: 10.1007/s12035-018-1319-y (opens in new tab)
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THC
Astrocytes
Cannabinoids
Glutamate
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