Maria E Secci

2 papers in the library · publishing 2013-2019

Papers

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Astrocytic Mechanisms Involving Kynurenic Acid Control Δ9-Tetrahydrocannabinol-Induced Increases in Glutamate Release in Brain Reward-Processing Areas.

Molecular Neurobiology May 2019 Maria E Secci, Paola Mascia, Claudia Sagheddu et al.

The reinforcing effects of Δ9-tetrahydrocannabinol (THC) in rats and monkeys, and the reinforcement-related dopamine-releasing effects of THC in rats, can be attenuated by increasing endogenous levels of kynurenic acid (KYNA) through systemic administration of the kynurenine 3-monooxygenase inhibitor, Ro 61-8048. KYNA is a negative allosteric modulator of α7 nicotinic acetylcholine receptors...

DOI: 10.1007/s12035-018-1319-y Full text THC Astrocytes Cannabinoids Glutamate +2

Reducing cannabinoid abuse and preventing relapse by enhancing endogenous brain levels of kynurenic acid.

Nature Neuroscience November 2013 Zuzana Justinova, Paola Mascia, Hui-Qiu Wu et al.

In the reward circuitry of the brain, α-7-nicotinic acetylcholine receptors (α7nAChRs) modulate effects of Δ(9)-tetrahydrocannabinol (THC), marijuana's main psychoactive ingredient. Kynurenic acid (KYNA) is an endogenous negative allosteric modulator of α7nAChRs. Here we report that the kynurenine 3-monooxygenase (KMO) inhibitor Ro 61-8048 increases brain KYNA levels and attenuates...

DOI: 10.1038/nn.3540 Full text