Altered cortico-striatal crosstalk underlies object recognition memory deficits in the sub-chronic phencyclidine model of schizophrenia.
Brain Structure and Function September 2017 Aman Asif-Malik, Daniel Dautan, Andrew M J Young et al.
The neural mechanisms underlying cognitive deficits in schizophrenia are poorly understood. Sub-chronic treatment with the NMDA antagonist phencyclidine (PCP) produces cognitive abnormalities in rodents that reliably model aspects of the neurocognitive alterations observed in schizophrenia. Given that network activity across regions encompassing medial prefrontal cortex (mPFC) and nucleus...
DOI: 10.1007/s00429-017-1393-3 (opens in new tab)
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Medial prefrontal cortex
Neurophysiology
Novel object recognition
Nucleus accumbens
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