Impaired limbic cortico-striatal structure and sustained visual attention in a rodent model of schizophrenia.
The International Journal of Neuropsychopharmacology October 31, 2014 Samuel A Barnes, Stephen J Sawiak, Daniele Caprioli et al.
N-methyl-d-aspartate receptor (NMDAR) dysfunction is thought to contribute to the pathophysiology of schizophrenia. Accordingly, NMDAR antagonists such as phencyclidine (PCP) are used widely in experimental animals to model cognitive impairment associated with this disorder. However, it is unclear whether PCP disrupts the structural integrity of brain areas relevant to the profile of cognitive...