Dissociation Does Not Mediate Antidepressant Response to Esketamine: A Real-World Longitudinal Study with 6-Month Follow-Up
European Psychiatry June 1, 2026 Miriam Olivola, V. Martiadis, Kevin la Monica et al.
Introduction The role of dissociation in mediating antidepressant response to intranasal esketamine remains debated. While dissociative experiences are often observed during treatment, their predictive value for clinical outcomes is uncertain. Objectives We aimed to assess whether (i) baseline dissociative traits (DES-II) and (ii) early changes in dissociation (ΔDES T0→T2) predict short-term...