Efficacy of Dextromethorphan Augmentation in SSRI‐Resistant Obsessive–Compulsive Disorder: A Randomized Controlled Trial
Health science reports May 1, 2026 Ahmad Zolghadriha, Afagh Anjomshoaa, Romina Bagheri
ABSTRACT: Background and Aims: Obsessive–compulsive disorder (OCD) is a chronic condition associated with marked functional impairment and high rates of treatment resistance. Converging evidence implicates glutamatergic dysregulation in OCD pathophysiology. Dextromethorphan (DXM), an N‐methyl‐ d ‐aspartate (NMDA) receptor antagonist with additional monoaminergic and sigma‐1 receptor activity,...