Basset Sophia

Age moderates the relationship between psychedelic use and mental health in naturalistic settings

Scientific Reports September 24, 2026 Giammarco di Gregorio, Basset Sophia, Harjot Manmohan et al.

Abstract Depression and anxiety affect one in five adults and vary across the lifespan; while prevalence generally declines with age until midlife, later life is marked by a re-emergence of symptoms. Although clinical trials suggest classic psychedelics (e.g., psilocybin, LSD) and non-classic psychedelics (e.g., MDMA, ketamine) may alleviate these symptoms, it remains unclear how these...