Does co-administration of cannabidiol (CBD) influence the plasma availability of delta-9-tetrahydrocannabinol (THC) and its active metabolite in humans? A systematic review and meta-analysis.
Neuroscience & Biobehavioral Reviews August 20, 2026 Lucy Chester, Heidar Sharafi, Amani Mahroug et al.
Research on the pharmacokinetic influence of cannabidiol (CBD) on delta-9-tetrahydrocannabinol (THC) has produced equivocal results. We conducted a systematic search following PRISMA guidelines (last search: 24th November 2025, PROSPERO: CRD42023480695). Included studies were acute dosing trials that administered a) a single, fixed dose of THC and b) a matched dose of THC co-administered with...
DOI: 10.1016/j.neubiorev.2026.106910 (opens in new tab)
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Cannabidiol
Tetrahydrocannabinol
Meta-analysis
Pharmacokinetics
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