Non-invasive proxies of cortical excitation--inhibition (E:I) balance, are increasingly used to understand human neural dynamics; especially so the aperiodic (1/f) electroencephalographic (EEG) exponent. Ketamine, an NMDA-receptor antagonist, is thought to shift this balance toward excitation. Propofol, a GABAA-receptor agonist, should behave oppositely. Here we show that these pharmacological...
Hong-Viet Victor Ngo, Henrik Oster, Christina Andreou et al.
preprint
Circadian rhythms are imprinted in all organisms and influence virtually all aspects of physiology and behaviour in adaptation to the 24-hour day-night cycle. This recognition of a circadian timekeeping system permeating essentially all healthy functioning of body and mind quickly leads to the realisation that, in turn, human ailments should be probed for the degree to which they are rooted in...