The novel non-hallucinogenic compound DM506 (3-methyl-1,2,3,4,5,6-hexahydroazepino[4,5-b]indole) induces sedative- and anxiolytic-like activity in mice by a mechanism involving 5-HT2A receptor activation.
European Journal of Pharmacology March 5, 2024 Hugo R Arias, Deborah Rudin, Dustin J. Hines et al. 12 citations
The anxiolytic and sedative-like effects of 3-methyl-1,2,3,4,5,6-hexahydroazepino[4,5-b]indole (DM506), a non-hallucinogenic compound derived from ibogamine, were studied in mice. The behavioral effects were examined using Elevated O-maze and novelty suppressed feeding (NSFT) tests, open field test, and loss of righting reflex (LORR) test. The results showed that 15 mg/kg DM506 induced acute...
DOI: 10.1016/j.ejphar.2024.176329 (opens in new tab)
Full text (opens in new tab)
5-ht2a/2b receptors
Anxiolytic activity
Ibogaminalog
Molecular docking
+1