Treatment-resistant depression (TRD) occurs when at least two different antidepressants, taken at the right dosage, for adequate period of time and with continuity, fail to give positive clinical effects. Esketamine, the S-enantiomer of ketamine, was recently approved for TRD treatment from U.S. Food and Drug Administration and European Medicine Agency. Despite proved clinical efficacy, many...
Objectives: This study aimed to assess:a) the socio-demographic characteristics of patients with schizophrenia who were using cannabis at time of first appearing of psychotic symptoms; b) the impact of cannabis on the duration of untreated psychosis (DUP) and on pathways to care; c) the influence of cannabis on the clinical onset and on the first three years of the disorder. Methods: Twenty-two...