Effects of esketamine on depression-like behavior and dendritic spine plasticity in the prefrontal cortex neurons of spared nerve injury-induced depressed mice.
Brazilian Journal of Medical and Biological Research 2024 Bixin Huang, Xiaoling Li, Yuling Zheng et al. 4 citations
The present study utilized the spared nerve injury (SNI) to create a mouse model of depression to investigate the impact of esketamine on depressive-like behaviors, on the expression of PSD-95 and CRMP2 proteins, and on changes in neuronal dendritic spine plasticity in the prefrontal cortex (PFC). Depressive-like behavioral tests were performed 1 h after esketamine treatment, and the PFC...
DOI: 10.1590/1414-431X2024e13736 (opens in new tab)
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Brain plasticity
Depression treatment
Esketamine therapy
Chronic pain