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Steven Erpelinck

1 paper in the library · publishing 2023

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17 Microdosing/microtracer based pediatric drug development

Archives of Disease in Childhood June 1, 2023 Esther van Duijn, Steven Erpelinck, Wouter Vaes

Introduction: An overview is given on the use of microdosing/microtracing studies for the safer and faster development of drugs in children. In a microdosing study a very small amount of radiolabelled (often 14C) drug is administered to a human volunteer. Using accelerator mass spectrometry extremely low amounts of the drug and metabolites can be traced and quantified. Methods: Several...