A V Deliganis

Differential interactions of dimethyltryptamine (DMT) with 5-HT1A and 5-HT2 receptors.

Biochemical Pharmacology June 1, 1991 A V Deliganis, P A Pierce, S J Peroutka

The interactions of the indolealkylamine N,N-dimethyltryptamine (DMT) with 5-hydroxytryptamine1A (5-HT1A) and 5-HT2 receptors in rat brain were analyzed using radioligand binding techniques and biochemical functional assays. The affinity of DMT for 5-HT1A sites labeled by [3H]-8-hydroxy-2-(di-n-propylamino)tetralin ([3H]-8-OH-DPAT) was decreased in the presence of 10(-4) M GTP, suggesting...