Methylenedioxymethamphetamine-induced serotonin deficits are followed by partial recovery over a 52-week period. Part I: Synaptosomal uptake and tissue concentrations.
Journal of Pharmacology and Experimental Therapeutics February 1, 1996 K E Sabol, R Lew, J B Richards et al.
The effects of a high dose methylenedioxymethamphetamine (MDMA) regimen on the serotonin (5-HT) system were evaluated over a 52-wk period. MDMA was administered to rats (20 mg/kg) 8 times at 12-hr intervals. Tissue concentrations of dopamine (DA) and 5-HT, and synaptosomal uptake of 3H-5-HT and 3H-DA were measured at 2, 8, 16, 32 or 52 wk posttreatment. Synaptosomal uptake of 3H-5-HT...
DOI: 10.1016/s0022-3565(25)12371-9 (opens in new tab)
Synaptosomes
Animals
Rats, sprague-dawley
Dopamine
+5