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Georgetta Vosmer

3 papers in the library · publishing 1987-1996

Papers

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Methylenedioxymethamphetamine-induced serotonin deficits are followed by partial recovery over a 52-week period. Part I: Synaptosomal uptake and tissue concentrations.

Journal of Pharmacology and Experimental Therapeutics February 1, 1996 K E Sabol, R Lew, J B Richards et al.

The effects of a high dose methylenedioxymethamphetamine (MDMA) regimen on the serotonin (5-HT) system were evaluated over a 52-wk period. MDMA was administered to rats (20 mg/kg) 8 times at 12-hr intervals. Tissue concentrations of dopamine (DA) and 5-HT, and synaptosomal uptake of 3H-5-HT and 3H-DA were measured at 2, 8, 16, 32 or 52 wk posttreatment. Synaptosomal uptake of 3H-5-HT...

DOI: 10.1016/s0022-3565(25)12371-9 (opens in new tab) Synaptosomes Animals Rats, sprague-dawley Dopamine +5

Long-term central 5-HT depletions resulting from repeated administration of MDMA enhances the effects of single administration of MDMA on schedule-controlled behavior of rats.

Pharmacology, Biochemistry, and Behavior July 1989 A A Li, Gerard J. Marek, Georgetta Vosmer et al.

The behavioral effect of single administration of +/- 3,4-methylene-dioxymethamphetamine (MDMA) on rats performing on the differential-reinforcement-of-low-rate 72-second schedule (DRL 72-sec) was compared before and after a period of repeated administration of MDMA known to deplete 5-hydroxytryptamine (5-HT) levels in the brain. Single administration of MDMA decreased reinforcement rate (1, 2,...

DOI: 10.1016/0091-3057(89)90402-4 (opens in new tab) Full text (opens in new tab)

Biochemical and histological evidence that methylenedioxymethylamphetamine (MDMA) is toxic to neurons in the rat brain.

Journal of Pharmacology and Experimental Therapeutics April 1, 1987 Deborah L. Commins, Georgetta Vosmer, R. Virus et al.

(+/-)-3,4-Methylenedioxymethylamphetamine (MDMA) was administered s.c. to rats (10, 20 or 40 mg/kg b. wt.) and guinea pigs (20 mg/kg) twice a day for 4 days, 2 weeks before decapitation. Norepinephrine, dopamine and serotonin (5-HT) levels were assayed in the hippocampus, hypothalamus, striatum and neocortex. In rats, MDMA produced dose-dependent reductions in 5-HT in all brain regions...

DOI: 10.1016/s0022-5347(25)00317-9 (opens in new tab)