Dennis Kätzel

Orbitofrontal PV interneurons modulate social interaction via default mode network dynamics.

Communications Biology April 24, 2026 Elmira Khatamsaz, Tudor M. Ionescu, Katja Keppler et al.

Social interactions are critical for mental health and are frequently disrupted in neuropsychiatric disorders. Clinical data suggest a link between dysfunction of the default mode network (DMN) and social impairment. To advance our understanding of the neurobiological mechanisms underlying social dysfunction, we back-translate these clinical findings into a preclinical setup, demonstrating that...