Prenatal Exposure to Δ9-Tetrahydrocannabinol Affects Hippocampus-Related Cognitive Functions in the Adolescent Rat Offspring: Focus on Specific Markers of Neuroplasticity.
Pharmaceutics February 17, 2023 Valentina Castelli, Gianluca Lavanco, Salvatore Feo et al.
Previous evidence suggests that prenatal exposure to THC (pTHC) derails the neurodevelopmental trajectories towards a vulnerable phenotype for impaired emotional regulation and limbic memory. Here we aimed to investigate pTHC effect on hippocampus-related cognitive functions and markers of neuroplasticity in adolescent male offspring. Wistar rats were exposed to THC (2 mg/kg) from gestational...
DOI: 10.3390/pharmaceutics15020692 (opens in new tab)
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Cb1r expression
Adolescent rat offspring
Hippocampal excitatory plasticity
Prenatal THC Exposure