We appreciate the opportunity to respond to the comments1 on our article2 and discuss the argument that “synergy is not just an outcome; it is also a process, and focusing just on outcomes may risk detracting from a holistic, accurate assessment of synergistic phenomena.” 1 As defined in dictionaries and in the clinical and statistical literatures, synergy is considered present when the “whole...
Clinical trials of psychedelics have provided support for their potential efficacy and safety.Although most combined a psychedelic with psychological support akin to psychotherapy, providing psychotherapy is costlier and more difficult to scale than providing only support to reduce harms.Trials with factorial designs can evaluate the individual effects of a psychedelic and psychotherapy and any...