Multi-state Model-Based Identification of Cryptic Allosteric Sites on Human Serotonin Transporter
ACS Chemical Neuroscience April 17, 2023 Gao Tu, Binbin Xu, Ding Luo et al. 15 citations
Serotonin transporter (SERT) plays a fundamental role in taking the synaptic cleft serotonin back to the presynaptic neuron. The discovery of allosteric SERT modulators represents the next-generation medication for psychiatric disorders such as depression. Here, based on the cryo-EM structures of ibogaine in complex with SERT in distinct conformations, the multiple functional structures of the...