CircKat6b Mediates the Antidepressant Effect of Esketamine by Regulating Astrocyte Function.
Molecular Neurobiology February 1, 2025 Na Hu, Yujie Zheng, Xueru Liu et al. 7 citations
The abundant expression of circular RNAs (circRNAs) in the central nervous system and their contribution to the pathogenesis of depression suggest that circRNAs are promising therapeutic targets for depression. This study explored the role and mechanism of circKat6b in esketamine's antidepressant effect. We found that intravenous administration of esketamine (5 mg/kg) treatment decreased the...