Lily C. Vonesh

2 papers in the library · 7 citations · publishing 2023-2026

Papers

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Effects of psilocybin with psychological support on anhedonia in treatment-resistant depression: A randomized controlled pilot trial.

Journal of Affective Disorders October 30, 2026 Andrew M Novick, Tiffany M Love, Rachel L Johnson et al.

Anhedonia is a core feature of major depressive disorder (MDD) that is frequently resistant to available treatments. Psilocybin's specific efficacy for anhedonia remains unclear. To evaluate psilocybin's efficacy for anhedonia in treatment-resistant MDD. In this randomized, double-blind, placebo-controlled trial, 20 participants with treatment-resistant MDD received psilocybin (25 mg or 1 mg)...

DOI: 10.1016/j.jad.2026.122676 Full text Psilocybin Treatment-resistant depression Anhedonia Randomized controlled trial

Propofol for treatment resistant depression: A randomized controlled trial

medRxiv September 15, 2023 Scott C. Tadler, Keith Jones, Carter Lybbert et al. 7 citations preprint

Background: Anesthetic agents including ketamine and nitrous oxide have shown antidepressant properties when appropriately dosed. Our recent open-label trial of propofol, an intravenous anesthetic known to elicit transient positive mood effects, suggested that it may also produce robust and durable antidepressant effects when administered at a high dose that elicits an electroencephalographic...

DOI: 10.1101/2023.09.12.23294678 Full text