medRxivSeptember 15, 2023Scott C. Tadler, Keith Jones, Carter Lybbert et al.7 citations
preprint
Background: Anesthetic agents including ketamine and nitrous oxide have shown antidepressant properties when appropriately dosed. Our recent open-label trial of propofol, an intravenous anesthetic known to elicit transient positive mood effects, suggested that it may also produce robust and durable antidepressant effects when administered at a high dose that elicits an electroencephalographic...