Depression and the Glutamate/GABA-Glutamine Cycle.
Current Neuropharmacology 2024 Mortimer Mamelak 24 citations
Many features of major depressive disorder are mirrored in rodent models of psychological stress. These models have been used to examine the relationship between the activation of the hypothalamic- pituitary axis in response to stress, the development of oxidative stress and neuroinflammation, the dominance of cholinergic neurotransmission and the associated increase in REM sleep pressure....