Decagram-Scale Synthesis of GB13 and Remodeling to the Galbulimima Alkaloids
Journal of the American Chemical Society September 17, 2026 Stephan M. Freeman, Eleanor M. Landwehr, Riku Tanaka et al.
Abstract Plants in the genus Galbulimima (GB) produce a series of neuroactive alkaloids that have proven impractical to obtain and study by isolation or chemical synthesis. The role of GB extracts in traditional Papuan medicine and ritual suggests that one or more alkaloids reach the brain by ingestion; identification of potent muscarinic and opioid receptor antagonists among the GB alkaloids...