Add-on intravenous ketamine eliminates treatment lag period in severe non-treatment-resistant major depression: Rapid antidepressant and anti-suicidal effects – A randomized controlled trial
Indian Journal of Psychiatry September 1, 2026 Anand Prakash, Pranab Mahapatra, Jigyansa I. Pattnaik et al.
ABSTRACT Background: The 4–12 week lag period of conventional antidepressants creates critical vulnerability in severe depression, with peak suicide risk during the first month. While ketamine research has focused on treatment-resistant populations, its potential to eliminate this lag period in non-treatment-resistant severe depression remains unexplored. Aims: To evaluate whether add-on...