Allosteric inhibition of NMDA receptors by low dose ketamine.
Molecular Psychiatry March 1, 2025 Jamie A Abbott, Han Wen, Beiying Liu et al. 14 citations
Ketamine, a general anesthetic, has rapid and sustained antidepressant effects when administered at lower doses. Anesthetic levels of ketamine reduce excitatory transmission by binding deep into the pore of NMDA receptors where it blocks current influx. In contrast, the molecular targets responsible for antidepressant levels of ketamine remain controversial. We used electrophysiology,...