Rethinking the role of TRKB in the action of antidepressants and psychedelics.
Trends in Neurosciences November 1, 2024 Cecilia Anna Brunello, Cecilia Cannarozzo, Eero Castrén 29 citations
Antidepressant drugs promote neuronal plasticity, and activation of brain-derived neurotrophic factor (BDNF) signaling through its receptor neuronal receptor tyrosine kinase 2 (NTRK2 or TRKB) is among the critical steps in this process. These mechanisms are shared by typical slow-acting antidepressants, fast-acting ketamine, and psychedelic compounds, although the cellular targets of each drug...