Han Wang

2 papers in the library · 5 citations · publishing 2023-2025

Papers

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(2R, 6R)-hydroxynorketamine ameliorates PTSD-like behaviors during the reconsolidation phase of fear memory in rats by modulating the VGF/BDNF/GluA1 signaling pathway in the hippocampus.

Behavioural Brain Research January 5, 2025 Han Wang, Yuxuan He, Jiahao Tang et al. 5 citations

Fear memory, a fundamental symptom of post-traumatic stress disorder (PTSD), is improved by (2R, 6R)-hydroxynorketamine ((2R, 6R)-HNK) administration. However, the phase of fear memory in which the injected drug is the most effective at mitigating PTSD-like effects remains unknown. This study aimed to explore the effects of (2 R, 6 R)-HNK administration during three phases [acquisition (AP),...

DOI: 10.1016/j.bbr.2024.115273 Full text 2r 6r-hydroxynorketamine Acquisition Extinc-tion +6

Ketamine alleviates fear memory and spatial cognition deficits in a PTSD rat model via the BDNF signaling pathway of the hippocampus and amygdala

Research Square July 3, 2023 Yue Teng, JiaYao Niu, Yang Liu et al. preprint

Abstract Background Post-traumatic stress disorder (PTSD) is associated with traumatic stress experiences. This condition can be accompanied by learning and cognitive deficits. Studies have demonstrated that ketamine can rapidly and significantly alleviate symptoms in patients with chronic PTSD. Nonetheless, the effects of ketamine on neurocognitive impairment and its mechanism of action in...

DOI: 10.21203/rs.3.rs-3116158/v1 Full text