Qilong Cheng

Decoding the molecular network communication mechanism of ketamine's antidepressant effects.

Psychopharmacology March 16, 2026 Ye Li, Qilong Cheng, Guoxin Lin et al.

RATIONALE: Major Depressive Disorder (MDD) is a global public health burden, with traditional monoaminergic antidepressants facing critical limitations including slow onset, adverse side effects, and high rates of treatment resistance (TRD). Ketamine, a rapid-acting agent with sustained antidepressant effects, has revolutionized depression treatment paradigms but challenges conventional...