Uncovering the Underlying Mechanisms of Ketamine as a Novel Antidepressant
Frontiers in Pharmacology July 7, 2022 Songbai Xu, Xiaoxiao Yao, Bingjin Li et al. 50 citations
Major depressive disorder (MDD) is a devastating psychiatric disorder which exacts enormous personal and social-economic burdens. Ketamine, an N-methyl-D-aspartate receptor (NMDAR) antagonist, has been discovered to exert rapid and sustained antidepressant-like actions on MDD patients and animal models. However, the dissociation and psychotomimetic propensities of ketamine have limited its use...