A novel Bacillus aerolatus CX253 alleviates dextromethorphan-induced neurotoxicity via modulating the microbiota-gut-brain axis and hippocampal Apelin signaling pathway.
Brain, behavior, and immunity May 1, 2026 Shihuan Tian, E. Huang, Guoxia Zhang et al.
The increasing non-medical use of dextromethorphan (DM), particularly among adolescents, has raised concerns regarding its potential neurobiological consequences. However, the precise mechanisms underlying its neurotoxicity, particularly the involvement of the gut microbiota, remain unclear. A novel probiotic strain, Bacillus aerolatus CX253, has demonstrated the capacity to regulate gut...