E X Albuquerque

Phencyclidine and some of its analogues have distinct effects on NMDA receptors of rat hippocampal neurons.

FEBS Letters August 1, 1988 A S Ramoa, E X Albuquerque

Phencyclidine (PCP) is a dissociative anesthetic agent which blocks the excitatory effect of N-methyl-D-aspartate (NMDA) in the central nervous system. To investigate the role of the PCP reactive site in the control of NMDA activation of hippocampal pyramidal cells, we have examined the action of PCP and some of its analogues on the response properties of single NMDA receptors. Application of...