Dextromethorphan and sigma ligands: common sites but diverse effects.
Life Science 1989 J. Musacchio, M. Klein, P. Canoll
There is increasing evidence that sigma ligands and dextromethorphan (DM) bind to at least one common high-affinity site. DM and other antitussives do not produce psychotomimetic effects. This suggested that sigma ligands may produce their characteristic effects through another site, and prompted us to review critically the literature on the side effects of sigma opiates. Contrary to what is...