Systemic or intrahippocampal cannabinoid administration impairs spatial memory in rats.
Psychopharmacology June 1995 A H Lichtman, K R Dimen, B R Martin
The purpose of the present study was to investigate the disruptive effects of cannabinoids on working memory as assessed in the eight-arm radial-maze. Systemic administration of delta 9-THC, WIN-55,212-2, and CP-55,940 increased the number of errors committed in the radial-maze. CP-55,940 was the most potent cannabinoid in impairing memory (ED50 = 0.13 mg/kg). delta 9-THC and WIN-55,212-2...