Assessment of the role of alpha-methylepinine in the neurotoxicity of MDMA.
Pharmacology, biochemistry, and behavior February 1991 T D Steele, W K Brewster, M P Johnson et al.
To assess the potential involvement of metabolism of 3,4-methylenedioxymethamphetamine (MDMA) to the catechol alpha-methylepinine in producing serotonergic neurotoxicity, we attempted to correlate aspects of this reaction with the neurotoxicity profile of MDMA. In contrast to the stereoselectivity of S-(+)-MDMA in causing persistent declines in rat brain 5-hydroxyindole levels, no...