Serotonin autoreceptors on dorsal raphe neurons: structure-activity relationships of tryptamine analogs
Journal of Neuroscience October 1, 1981 MA Rogawaski, G K Aghajanian 52 citations
A series of indole-ethylamines were tested for their ability to suppress the spontaneous firing of single dorsal raphe serotonergic neurons in the rat. The compounds were all derivatives of either tryptamine or N,N-dimethyltryptamine possessing hydroxy or methoxy substituents on the benzene ring portion of the indole nucleus. Their activity was assessed using quantitative microiontophoresis or...