Repeated administration of MDMA causes transient down-regulation of serotonin 5-HT2 receptors.
Neuropharmacology September 1992 Ursula Scheffel, John R. Lever, M Stathis et al.
The present study examined short- and long-term effects of MDMA (3,4-methylene-dioxymethamphetamine) on serotonin (5-HT2 and 5-HT1c) receptors in the brain of the rat. N1-Methyl-2-[125I]lysergic acid diethylamide ([125I]MIL) was used to label these receptors in vitro and in vivo. The usefulness of [125I]MIL for in vivo detection of changes in 5-HT2 receptors was confirmed in preliminary...