753. The Mechanism of Ketamine’s Anti-Suicidal Action: From Glutamatergic Surge to Neuroplasticity via the Opioid-Attachment Interface
International Journal of Neuropsychopharmacology September 9, 2026 A Solomon, Y Domany
Abstract Background A critical gap exists in understanding the biological mechanism linking ketamine’s rapid anti-suicidal effects to the Interpersonal Theory of Suicide (IPTS). While the "Kinetic Mismatch" between acute relief and delayed synaptogenesis is well-known, current models overlook how ketamine modulates “Thwarted Belongingness” (a core IPTS pillar) and the attachment anxiety that...