Dose-dependent effect of ketamine on functional connectivity in mice
bioRxiv (Cold Spring Harbor Laboratory) September 8, 2026 Tomokazu Tsurugizawa, Aya Takemura preprint
A single injection of a subanesthetic dose of ketamine, an NMDA receptor antagonist, induces schizophrenia-like behavior in mice. Previous studies investigated the effect of single injection of ketamine on behavior and c-Fos expression in mice dose-dependently. However, there has not been functional magnetic resonance imaging (fMRI) study to investigate the effect of ketamine in mice. Here, we...