Apical integration theory provides a neural basis for understanding disorganization and consciousness in the schizophrenias
Current Research in Neurobiology July 1, 2026 S. Silverstein, T. Zolnik, M. Larkum et al.
Recent discoveries involving pyramidal neurons with two zones of input integration (apical and basal), the contextual information they provide, and the neural circuitry and neuromodulation systems in which they are embedded, can contribute to our understanding of disorganized symptoms in schizophrenia, including changes in their expression from the prodromal to chronic stages of the disorder....