Jan Kasper

Local activity alterations in autism spectrum disorder correlate with neurotransmitter properties and ketamine induced brain changes.

medRxiv October 21, 2024 Pascal Grumbach, Jan Kasper, Joerg F. Hipp et al. 1 citation preprint

Autism spectrum disorder (ASD) is a neurodevelopmental condition associated with altered resting-state brain function. An increased excitation-inhibition (E/I) ratio is discussed as a potential pathomechanism but in-vivo evidence of disturbed neurotransmission underlying these functional alterations remains scarce. We compared rs-fMRI local activity (LCOR) between ASD (N=405, N=395) and...