Local activity alterations in autism spectrum disorder correlate with neurotransmitter properties and ketamine induced brain changes.
medRxiv : the preprint server for health sciences October 21, 2024 Pascal Grumbach, Jan Kasper, Joerg F. Hipp et al. 1 citation preprint
Autism spectrum disorder (ASD) is a neurodevelopmental condition associated with altered resting-state brain function. An increased excitation-inhibition (E/I) ratio is discussed as a potential pathomechanism but in-vivo evidence of disturbed neurotransmission underlying these functional alterations remains scarce. We compared rs-fMRI local activity (LCOR) between ASD (N=405, N=395) and...