Changes in gene expression after phencyclidine administration in developing rats: a potential animal model for schizophrenia.
International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience May 2011 F Liu, X Zou, N Sadovova et al.
Repeated administration of phencyclidine (PCP), an N-methyl-d-aspartate (NMDA) receptor antagonist, during development, may result in neuronal damage that leads to behavioral deficits in adulthood. The present study examined the potential neurotoxic effects of PCP exposure (10mg/kg) in rats on postnatal days (PNDs) 7, 9 and 11 and the possible underlying mechanism(s) for neurotoxicity. Brain...