Absence of delta -9-tetrahydrocannabinol dysphoric effects in dynorphin-deficient mice.
The Journal of neuroscience : the official journal of the Society for Neuroscience December 1, 2001 A Zimmer, E Valjent, M Konig et al.
The involvement of dynorphin on Delta-9-tetrahydrocannabinol (THC) and morphine responses has been investigated by using mice with a targeted inactivation of the prodynorphin (Pdyn) gene. Dynorphin-deficient mice show specific changes in the behavioral effects of THC, including a reduction of spinal THC analgesia and the absence of THC-induced conditioned place aversion. In contrast, acute and...