Nurith Amitai

2 papers in the library · publishing 2007-2019

Papers

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Phencyclidine increased while isolation rearing did not affect progressive ratio responding in rats: Investigating potential models of amotivation in schizophrenia.

Behavioural Brain Research May 17, 2019 Nurith Amitai, Susan B Powell, Jared W Young

Schizophrenia is a debilitating neurodevelopmental disorder affecting 1% of the global population with heterogeneous symptoms including positive, negative, and cognitive. While treatment for positive symptoms exists, none have been developed to treat negative symptoms. Animal models of schizophrenia are required to test targeted treatments and since patients exhibit reduced effort (breakpoints)...

DOI: 10.1016/j.bbr.2017.11.026 Full text Breakpoints Environment Motivation Nmda +1

Cognitive-disruptive effects of the psychotomimetic phencyclidine and attenuation by atypical antipsychotic medications in rats.

Psychopharmacology September 2007 Nurith Amitai, Svetlana Semenova, Athina Markou

Cognitive deficits in schizophrenia are severe and do not respond well to available treatments. The development and validation of animal models of cognitive deficits characterizing schizophrenia are crucial for clarifying the underlying neuropathology and discovery of improved treatments for such deficits. We investigated whether single and repeated administrations of the psychotomimetic...

DOI: 10.1007/s00213-007-0808-x Full text